Assay Detail
Functional
CHEMBL3089270
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Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.02 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228814 | ISPINESIB | 2.0 | 1 | 6.00 |
| CHEMBL3087419 | — | — | 1 | 5.37 |
| CHEMBL3087418 | — | — | 1 | 5.31 |
| CHEMBL3087420 | — | — | 1 | 5.28 |
| CHEMBL3087430 | — | — | 1 | 5.11 |
| CHEMBL3087429 | — | — | 1 | 5.05 |
| CHEMBL3087428 | — | — | 1 | 5.02 |
| CHEMBL3087426 | — | — | 1 | 4.99 |
| CHEMBL3087427 | — | — | 1 | 4.97 |
| CHEMBL3087425 | — | — | 1 | 4.95 |
| CHEMBL3087417 | — | — | 1 | 4.89 |
| CHEMBL3087414 | — | — | 1 | 4.86 |
| CHEMBL3087416 | — | — | 1 | 4.85 |
| CHEMBL3087415 | — | — | 1 | 4.83 |
| CHEMBL3087421 | — | — | 1 | 4.82 |
| CHEMBL3087424 | — | — | 1 | 4.77 |
| CHEMBL3087422 | — | — | 1 | 4.75 |
| CHEMBL3085794 | — | — | 1 | 4.75 |
| CHEMBL3087423 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228814 | ISPINESIB | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3087419 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3087418 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3087420 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3087430 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3087429 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3087428 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3087426 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL3087427 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3087425 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3087417 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL3087414 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3087416 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3087415 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL3087421 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL3087424 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL3087422 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL3085794 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL3087423 | — | IC50 | = | 18900.0 | nM | 4.72 |