Assay Detail
Functional
CHEMBL3089313
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Photocytotoxicity against human KB cells overexpressing folate receptor assessed as cell viability incubated for 24 hrs followed by halogen light illumination measured after 20 mins by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preparation and in vitro photodynamic activities of folate-conjugated distyryl boron dipyrromethene based photosensitizers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.99 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3087008 | — | — | 1 | 7.70 |
| CHEMBL3087156 | — | — | 1 | 7.22 |
| CHEMBL3087157 | — | — | 1 | 6.75 |
| CHEMBL1622 | FOLIC ACID | 4.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3087008 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3087156 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3087157 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1622 | FOLIC ACID | IC50 | = | 500.0 | nM | 6.30 |