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Assay Detail

CHEMBL3089324

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at human S1P1 receptor expressed in CHO cells after 120 mins by [35S]GTPgammaS binding assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sphingosine 1-phosphate receptor 1 (CHEMBL4333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Modulators of the Sphingosine 1-phosphate receptor 1.
Urbano M, Guerrero M, Rosen H, Roberts E.
Bioorg Med Chem Lett (2013) 23 : 6377 -6389
PubMed 24125884 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.70 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3086703 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3086703 IC50 = 2.0 nM 8.70