Assay Detail
Binding
CHEMBL3090249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ecto-5'-nucleotidase expressed in african green monkey COS7 cells using adenosine monophosphate as substrate preincubated for 10 mins before substrate addition measured after 10 mins by capillary electrophoresis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.81 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3087995 | — | — | 1 | 5.88 |
| CHEMBL3088000 | — | — | 1 | 5.21 |
| CHEMBL1566888 | — | — | 1 | 5.09 |
| CHEMBL1339340 | — | — | 1 | 4.87 |
| CHEMBL60494 | — | — | 1 | 4.66 |
| CHEMBL3087996 | — | — | 1 | 4.52 |
| CHEMBL3087999 | — | — | 1 | 4.39 |
| CHEMBL68253 | SULFAMATE | — | 1 | 4.38 |
| CHEMBL3087998 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3087995 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3088000 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1566888 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1339340 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL60494 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL3087996 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL3087999 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL68253 | SULFAMATE | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL3087998 | — | IC50 | = | 47600.0 | nM | 4.32 |