Assay Detail
Binding
CHEMBL3090349
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Binding affinity to human recombinant TTR Y78F mutant after 5 mins by isothermal titration calorimetry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Modulation of the fibrillogenesis inhibition properties of two transthyretin ligands by halogenation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 6.74 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3088246 | — | — | 1 | 7.19 |
| CHEMBL3088247 | — | — | 1 | 7.07 |
| CHEMBL3088245 | — | — | 1 | 7.07 |
| CHEMBL1232738 | — | — | 1 | 7.06 |
| CHEMBL3088244 | — | — | 1 | 7.04 |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 6.96 |
| CHEMBL3088250 | — | — | 1 | 6.71 |
| CHEMBL3088249 | — | — | 1 | 6.43 |
| CHEMBL3088248 | — | — | 1 | 5.95 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3088246 | — | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL3088247 | — | Kd | = | 85.0 | nM | 7.07 |
| CHEMBL3088245 | — | Kd | = | 86.0 | nM | 7.07 |
| CHEMBL1232738 | — | Kd | = | 87.0 | nM | 7.06 |
| CHEMBL3088244 | — | Kd | = | 91.0 | nM | 7.04 |
| CHEMBL23588 | FLUFENAMIC ACID | Kd | = | 109.0 | nM | 6.96 |
| CHEMBL3088250 | — | Kd | = | 194.0 | nM | 6.71 |
| CHEMBL3088249 | — | Kd | = | 375.0 | nM | 6.43 |
| CHEMBL3088248 | — | Kd | = | 1120.0 | nM | 5.95 |
| CHEMBL898 | DIFLUNISAL | Kd | = | 1160.0 | nM | 5.94 |