Assay Detail
Functional
CHEMBL3090716
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Leishmanicidal activity against intracellular amastigote stage of Leishmania amazonensis MHOM/Br/79/Maria infected in mouse J774 cells assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo antileishmanial and trypanocidal studies of new N-benzene- and N-naphthalenesulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.44 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085903 | — | — | 1 | 4.75 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.68 |
| CHEMBL3085895 | — | — | 1 | 4.51 |
| CHEMBL3085886 | — | — | 1 | 4.37 |
| CHEMBL3085892 | — | — | 1 | 4.19 |
| CHEMBL3085901 | — | — | 1 | 4.11 |
| CHEMBL3085899 | — | — | 1 | - |
| CHEMBL424146 | — | — | 1 | - |
| CHEMBL594928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085903 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL3085895 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL3085886 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL3085892 | — | IC50 | = | 64100.0 | nM | 4.19 |
| CHEMBL3085901 | — | IC50 | = | 77500.0 | nM | 4.11 |
| CHEMBL3085899 | — | IC50 | - | — | - | |
| CHEMBL424146 | — | IC50 | - | — | - | |
| CHEMBL594928 | — | IC50 | - | — | - |