Assay Detail
Functional
CHEMBL3090726
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Leishmanicidal activity against extracellular promastigote stage of Leishmania amazonensis MHOM/Br/79/Maria assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo antileishmanial and trypanocidal studies of new N-benzene- and N-naphthalenesulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.48 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085894 | — | — | 1 | 5.13 |
| CHEMBL3085885 | — | — | 1 | 5.08 |
| CHEMBL3085893 | — | — | 1 | 4.90 |
| CHEMBL3085889 | — | — | 1 | 4.85 |
| CHEMBL3085892 | — | — | 1 | 4.81 |
| CHEMBL3085890 | — | — | 1 | 4.80 |
| CHEMBL3085891 | — | — | 1 | 4.74 |
| CHEMBL3085903 | — | — | 1 | 4.61 |
| CHEMBL3085886 | — | — | 1 | 4.61 |
| CHEMBL3085905 | — | — | 1 | 4.57 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.47 |
| CHEMBL3085897 | — | — | 1 | 4.42 |
| CHEMBL3085895 | — | — | 1 | 4.41 |
| CHEMBL3085902 | — | — | 1 | 4.39 |
| CHEMBL3085888 | — | — | 1 | 4.33 |
| CHEMBL424146 | — | — | 1 | 4.23 |
| CHEMBL3085898 | — | — | 1 | 4.22 |
| CHEMBL594199 | — | — | 1 | 4.18 |
| CHEMBL593264 | — | — | 1 | 4.16 |
| CHEMBL3085906 | — | — | 1 | 4.08 |
| CHEMBL3085901 | — | — | 1 | 4.08 |
| CHEMBL3085900 | — | — | 1 | 4.05 |
| CHEMBL3085907 | — | — | 1 | 4.03 |
| CHEMBL3085896 | — | — | 1 | - |
| CHEMBL3085887 | — | — | 1 | - |
| CHEMBL3085899 | — | — | 1 | - |
| CHEMBL594928 | — | — | 1 | - |
| CHEMBL3085904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085894 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3085885 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3085893 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3085889 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3085892 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL3085890 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL3085891 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL3085903 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL3085886 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL3085905 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL3085897 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL3085895 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL3085902 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL3085888 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL424146 | — | IC50 | = | 59100.0 | nM | 4.23 |
| CHEMBL3085898 | — | IC50 | = | 60300.0 | nM | 4.22 |
| CHEMBL594199 | — | IC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL593264 | — | IC50 | = | 68600.0 | nM | 4.16 |
| CHEMBL3085906 | — | IC50 | = | 82800.0 | nM | 4.08 |
| CHEMBL3085901 | — | IC50 | = | 82600.0 | nM | 4.08 |
| CHEMBL3085900 | — | IC50 | = | 89600.0 | nM | 4.05 |
| CHEMBL3085907 | — | IC50 | = | 93500.0 | nM | 4.03 |
| CHEMBL3085896 | — | IC50 | = | 115700.0 | nM | - |
| CHEMBL3085887 | — | IC50 | = | 197700.0 | nM | - |
| CHEMBL3085899 | — | IC50 | = | 107900.0 | nM | - |
| CHEMBL594928 | — | IC50 | - | — | - | |
| CHEMBL3085904 | — | IC50 | - | — | - |