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Assay Detail

CHEMBL3090830

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to 5HT2A receptor (unknown origin) by radioligand binding assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Polypharmacology - foe or friend?
Peters JU.
J Med Chem (2013) 56 : 8955 -8971
PubMed 23919353 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 7.59 8.47
Ki 1 9.40 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL708 ZIPRASIDONE 4.0 1 9.40
CHEMBL71 CHLORPROMAZINE 4.0 1 8.47
CHEMBL643 PROMETHAZINE 4.0 1 7.64
CHEMBL11 IMIPRAMINE 4.0 1 6.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL708 ZIPRASIDONE Ki = 0.4 nM 9.40
CHEMBL71 CHLORPROMAZINE IC50 = 3.4 nM 8.47
CHEMBL643 PROMETHAZINE IC50 = 23.0 nM 7.64
CHEMBL11 IMIPRAMINE IC50 = 220.0 nM 6.66