Assay Detail

CHEMBL3091193

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Binding

Inhibition of ROCK2 (unknown origin)

ChEMBL ↗

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Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Open DB target context

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Primary target Rho-associated protein kinase 2

CHEMBL2973

Anchored from Assay target.

Protein identity Rho-associated protein kinase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors.

Guan R, Xu X, Chen M, Hu H, Ge H, Wen S, Zhou S, Pi R.
Eur J Med Chem (2013) 70 : 613 -622
PubMed 24211637 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.80	6.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL38380	FASUDIL	3.0	1	6.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL38380	FASUDIL	IC50	=	158.0	nM	6.80