Assay Detail
Binding
CHEMBL3094589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human wild type 5-HT3A receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 9.39 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1189679 | PALONOSETRON | 4.0 | 1 | 9.49 |
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | 9.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1189679 | PALONOSETRON | Kd | = | 0.32 | nM | 9.49 |
| CHEMBL289469 | GRANISETRON | Kd | = | 0.53 | nM | 9.28 |