Assay Detail
Binding
CHEMBL3094800
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Inhibition of human recombinant MAO-B using benzylamine as substrate preincubated for 15 mins under dark condition followed by substrate addition measured after 20 mins by fluorescence assay
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.78 | 6.73 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 6.73 |
| CHEMBL3093174 | — | — | 1 | 6.40 |
| CHEMBL3093176 | — | — | 1 | 6.36 |
| CHEMBL3093175 | — | — | 1 | 6.29 |
| CHEMBL3093178 | — | — | 1 | 5.99 |
| CHEMBL450675 | BONDUCELLIN | — | 1 | 5.97 |
| CHEMBL3093172 | — | — | 1 | 5.96 |
| CHEMBL3093180 | — | — | 1 | 5.96 |
| CHEMBL3093173 | — | — | 1 | 5.94 |
| CHEMBL3093179 | — | — | 1 | 5.91 |
| CHEMBL3093170 | — | — | 1 | 5.87 |
| CHEMBL3093171 | — | — | 1 | 5.81 |
| CHEMBL3093167 | — | — | 1 | 5.75 |
| CHEMBL3093166 | — | — | 1 | 5.66 |
| CHEMBL3093177 | — | — | 1 | 5.46 |
| CHEMBL3093181 | — | — | 1 | 4.81 |
| CHEMBL3093168 | — | — | 1 | 4.71 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 4.43 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL673 | PARGYLINE | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL3093174 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL3093176 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL3093175 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL3093178 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL450675 | BONDUCELLIN | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3093172 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL3093180 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3093173 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL3093179 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL3093170 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL3093171 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL3093167 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL3093166 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3093177 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL3093181 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL3093168 | — | IC50 | = | 19730.0 | nM | 4.71 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL8706 | CLORGILINE | Inhibition | - | % | - |