Assay Detail
Functional
CHEMBL3095273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 5.51 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3091935 | — | — | 1 | 6.22 |
| CHEMBL3091939 | — | — | 1 | 6.16 |
| CHEMBL3091934 | — | — | 1 | 6.16 |
| CHEMBL3091938 | — | — | 1 | 6.10 |
| CHEMBL3091937 | — | — | 1 | 6.10 |
| CHEMBL3091468 | — | — | 1 | 6.10 |
| CHEMBL3091952 | — | — | 1 | 6.10 |
| CHEMBL3091951 | — | — | 1 | 6.05 |
| CHEMBL3091936 | — | — | 1 | 6.00 |
| CHEMBL3091940 | — | — | 1 | 6.00 |
| CHEMBL3091949 | — | — | 1 | 6.00 |
| CHEMBL3091963 | — | — | 1 | 5.82 |
| CHEMBL33859 | — | — | 1 | 5.66 |
| CHEMBL3091945 | — | — | 1 | 5.66 |
| CHEMBL3091950 | — | — | 1 | 5.62 |
| CHEMBL3091962 | — | — | 1 | 5.55 |
| CHEMBL3091961 | — | — | 1 | 5.54 |
| CHEMBL174325 | — | — | 1 | 5.28 |
| CHEMBL3091956 | — | — | 1 | 5.28 |
| CHEMBL3091947 | — | — | 1 | 5.21 |
| CHEMBL3091964 | — | — | 1 | 5.16 |
| CHEMBL3091953 | — | — | 1 | 5.11 |
| CHEMBL174112 | — | — | 1 | 5.08 |
| CHEMBL3091948 | — | — | 1 | 5.07 |
| CHEMBL3091933 | — | — | 1 | 5.04 |
| CHEMBL3091955 | — | — | 1 | 5.02 |
| CHEMBL3091958 | — | — | 1 | 4.96 |
| CHEMBL3091957 | — | — | 1 | 4.85 |
| CHEMBL3091946 | — | — | 1 | 4.75 |
| CHEMBL3091932 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3091935 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3091939 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3091934 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3091938 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3091937 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3091468 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3091952 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3091951 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3091936 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3091940 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3091949 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3091963 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL33859 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3091945 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3091950 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3091962 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3091961 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL174325 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3091956 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3091947 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3091964 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3091953 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL174112 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3091948 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3091933 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3091955 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3091958 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3091957 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3091946 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3091932 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3091954 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3091959 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3091960 | — | EC50 | > | 30000.0 | nM | - |