Assay Detail
Functional
CHEMBL3095274
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Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 5.53 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3091937 | — | — | 1 | 6.40 |
| CHEMBL3091936 | — | — | 1 | 6.40 |
| CHEMBL3091939 | — | — | 1 | 6.40 |
| CHEMBL3091935 | — | — | 1 | 6.30 |
| CHEMBL3091940 | — | — | 1 | 6.30 |
| CHEMBL3091938 | — | — | 1 | 6.22 |
| CHEMBL3091963 | — | — | 1 | 6.00 |
| CHEMBL33859 | — | — | 1 | 5.85 |
| CHEMBL3091962 | — | — | 1 | 5.80 |
| CHEMBL3091932 | — | — | 1 | 5.77 |
| CHEMBL3091961 | — | — | 1 | 5.75 |
| CHEMBL174325 | — | — | 1 | 5.70 |
| CHEMBL3091468 | — | — | 1 | 5.66 |
| CHEMBL3091952 | — | — | 1 | 5.55 |
| CHEMBL3091957 | — | — | 1 | 5.55 |
| CHEMBL174112 | — | — | 1 | 5.44 |
| CHEMBL3091949 | — | — | 1 | 5.42 |
| CHEMBL3091958 | — | — | 1 | 5.40 |
| CHEMBL3091945 | — | — | 1 | 5.40 |
| CHEMBL3091956 | — | — | 1 | 5.39 |
| CHEMBL3091953 | — | — | 1 | 5.36 |
| CHEMBL3091954 | — | — | 1 | 5.34 |
| CHEMBL3091934 | — | — | 1 | 5.29 |
| CHEMBL3091947 | — | — | 1 | 5.25 |
| CHEMBL3091933 | — | — | 1 | 5.24 |
| CHEMBL3091948 | — | — | 1 | 5.21 |
| CHEMBL3091946 | — | — | 1 | 5.11 |
| CHEMBL3091951 | — | — | 1 | 5.08 |
| CHEMBL3091955 | — | — | 1 | 5.08 |
| CHEMBL3091950 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3091937 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3091939 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3091936 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3091935 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3091940 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3091938 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3091963 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL33859 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3091962 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3091932 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3091961 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL174325 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3091468 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3091952 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3091957 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL174112 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3091949 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3091958 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3091945 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3091956 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3091953 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3091954 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3091934 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3091947 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3091933 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3091948 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3091946 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3091951 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3091955 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3091950 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3091960 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3091959 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3091964 | — | EC50 | = | 24000.0 | nM | 4.62 |