Assay Detail
Binding
CHEMBL3095441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from Sprague-Dawley rat brain frontal cortex NET by scintillation counting analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.89 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3094183 | — | — | 1 | 6.91 |
| CHEMBL3094176 | — | — | 1 | 6.75 |
| CHEMBL3094178 | — | — | 1 | 6.58 |
| CHEMBL3094157 | — | — | 1 | 6.57 |
| CHEMBL3094175 | — | — | 1 | 6.56 |
| CHEMBL3094191 | — | — | 1 | 6.55 |
| CHEMBL3094177 | — | — | 1 | 6.35 |
| CHEMBL3094193 | — | — | 1 | 6.18 |
| CHEMBL3094192 | — | — | 1 | 6.17 |
| CHEMBL3094163 | — | — | 1 | 5.99 |
| CHEMBL3094160 | — | — | 1 | 5.89 |
| CHEMBL3094180 | — | — | 1 | 5.86 |
| CHEMBL3094194 | — | — | 1 | 5.63 |
| CHEMBL3094170 | — | — | 1 | 5.55 |
| CHEMBL3094165 | — | — | 1 | 5.32 |
| CHEMBL3094172 | — | — | 1 | 5.30 |
| CHEMBL3094161 | — | — | 1 | 5.29 |
| CHEMBL3094171 | — | — | 1 | 5.15 |
| CHEMBL3094197 | — | — | 1 | 5.08 |
| CHEMBL3094188 | — | — | 1 | 4.96 |
| CHEMBL3094166 | — | — | 1 | 4.95 |
| CHEMBL3094187 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3094183 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL3094176 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL3094178 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL3094157 | — | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL3094175 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL3094191 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL3094177 | — | Ki | = | 448.0 | nM | 6.35 |
| CHEMBL3094193 | — | Ki | = | 653.0 | nM | 6.18 |
| CHEMBL3094192 | — | Ki | = | 683.0 | nM | 6.17 |
| CHEMBL3094163 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL3094160 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3094180 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL3094194 | — | Ki | = | 2330.0 | nM | 5.63 |
| CHEMBL3094170 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL3094165 | — | Ki | = | 4750.0 | nM | 5.32 |
| CHEMBL3094172 | — | Ki | = | 4970.0 | nM | 5.30 |
| CHEMBL3094161 | — | Ki | = | 5090.0 | nM | 5.29 |
| CHEMBL3094171 | — | Ki | = | 7020.0 | nM | 5.15 |
| CHEMBL3094197 | — | Ki | = | 8280.0 | nM | 5.08 |
| CHEMBL3094188 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL3094166 | — | Ki | = | 11300.0 | nM | 4.95 |
| CHEMBL3094187 | — | Ki | > | 80000.0 | nM | - |