Assay Detail
Binding
CHEMBL3095464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bcl-xL (1 to 206, delta 45 to 84)-BAK (unknown origin) protein interaction by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biochemical evaluation of highly enantiomerically pure (R,R)- and (S,S)-alexidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.67 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554041 | ALEXIDINE DIHYDROCHLORIDE | — | 1 | 4.74 |
| CHEMBL3217259 | — | — | 1 | 4.67 |
| CHEMBL3216600 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554041 | ALEXIDINE DIHYDROCHLORIDE | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL3217259 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL3216600 | — | IC50 | = | 25700.0 | nM | 4.59 |