Assay Detail
Binding
CHEMBL3095478
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Displacement of [3H]methyllycaconitine from Sprague-Dawley rat brain alpha7 nAChR after 120 mins by liquid scintillation counting analysis
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 47 | 6.27 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497939 | CYTISINICLINE | 3.0 | 1 | 6.58 |
| CHEMBL3093669 | — | — | 1 | 5.96 |
| CHEMBL3093708 | — | — | 1 | - |
| CHEMBL3093709 | — | — | 1 | - |
| CHEMBL3093664 | — | — | 1 | - |
| CHEMBL3093665 | — | — | 1 | - |
| CHEMBL3093666 | — | — | 1 | - |
| CHEMBL3093701 | — | — | 1 | - |
| CHEMBL3093668 | — | — | 1 | - |
| CHEMBL3093670 | — | — | 1 | - |
| CHEMBL3093671 | — | — | 1 | - |
| CHEMBL3093672 | — | — | 1 | - |
| CHEMBL3093673 | — | — | 1 | - |
| CHEMBL3093674 | — | — | 1 | - |
| CHEMBL3093675 | — | — | 1 | - |
| CHEMBL3093676 | — | — | 1 | - |
| CHEMBL3093677 | — | — | 1 | - |
| CHEMBL3093678 | — | — | 1 | - |
| CHEMBL3093679 | — | — | 1 | - |
| CHEMBL3093680 | — | — | 1 | - |
| CHEMBL3093681 | — | — | 1 | - |
| CHEMBL3093682 | — | — | 1 | - |
| CHEMBL3093683 | — | — | 1 | - |
| CHEMBL3093684 | — | — | 1 | - |
| CHEMBL3093685 | — | — | 1 | - |
| CHEMBL3093686 | — | — | 1 | - |
| CHEMBL3093687 | — | — | 1 | - |
| CHEMBL3093688 | — | — | 1 | - |
| CHEMBL3093690 | — | — | 1 | - |
| CHEMBL3093689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497939 | CYTISINICLINE | Ki | = | 261.0 | nM | 6.58 |
| CHEMBL3093669 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3093666 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093691 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3093665 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093664 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093709 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093708 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093707 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093706 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093705 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093704 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093703 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093702 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093667 | — | Ki | - | — | - | |
| CHEMBL3093700 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3093699 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093698 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093697 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093696 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093695 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093694 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093693 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093692 | — | Ki | - | — | - | |
| CHEMBL3093679 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093689 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093690 | — | Ki | - | — | - | |
| CHEMBL3093688 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093687 | — | Ki | - | — | - | |
| CHEMBL3093686 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3093685 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093684 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3093683 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093682 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3093681 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093680 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093701 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093678 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093677 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093676 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3093675 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3093674 | — | Ki | - | — | - | |
| CHEMBL3093673 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093672 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093671 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093670 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093668 | — | Ki | > | 10000.0 | nM | - |