Assay Detail
Binding
CHEMBL3095598
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Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.52 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32823 | — | — | 1 | 9.77 |
| CHEMBL3093791 | — | — | 1 | 8.59 |
| CHEMBL3093787 | — | — | 1 | 8.20 |
| CHEMBL3093789 | — | — | 1 | 7.62 |
| CHEMBL3093788 | — | — | 1 | 7.58 |
| CHEMBL3093790 | — | — | 1 | 7.50 |
| CHEMBL3093786 | — | — | 1 | 7.15 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.96 |
| CHEMBL3093785 | — | — | 1 | 6.82 |
| CHEMBL3093793 | — | — | 1 | 6.37 |
| CHEMBL3093792 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32823 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL3093791 | — | IC50 | = | 2.55 | nM | 8.59 |
| CHEMBL3093787 | — | IC50 | = | 6.32 | nM | 8.20 |
| CHEMBL3093789 | — | IC50 | = | 24.14 | nM | 7.62 |
| CHEMBL3093788 | — | IC50 | = | 26.49 | nM | 7.58 |
| CHEMBL3093790 | — | IC50 | = | 31.98 | nM | 7.50 |
| CHEMBL3093786 | — | IC50 | = | 70.77 | nM | 7.15 |
| CHEMBL95 | TACRINE | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL3093785 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL3093793 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL3093792 | — | IC50 | = | 657.0 | nM | 6.18 |