Assay Detail
Binding
CHEMBL3095666
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Inhibition of human recombinant carbonic anhydrase 2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.86 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL3092749 | — | — | 1 | 6.62 |
| CHEMBL3092750 | — | — | 1 | 6.51 |
| CHEMBL1467754 | — | — | 1 | 6.41 |
| CHEMBL594100 | N,N'-DISALICYLALETHYLENEDIAMINE | — | 1 | 5.76 |
| CHEMBL3092751 | — | — | 1 | 5.50 |
| CHEMBL3092748 | — | — | 1 | 5.47 |
| CHEMBL1985188 | — | — | 1 | 5.47 |
| CHEMBL3092747 | — | — | 1 | 5.45 |
| CHEMBL1163022 | — | — | 1 | 5.44 |
| CHEMBL256208 | — | — | 1 | 5.43 |
| CHEMBL593618 | — | — | 1 | 5.41 |
| CHEMBL593165 | — | — | 1 | 5.38 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 5.26 |
| CHEMBL3092746 | — | — | 1 | - |
| CHEMBL3092752 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3092749 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3092750 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL1467754 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL594100 | N,N'-DISALICYLALETHYLENEDIAMINE | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL3092751 | — | Ki | = | 3130.0 | nM | 5.50 |
| CHEMBL3092748 | — | Ki | = | 3390.0 | nM | 5.47 |
| CHEMBL1985188 | — | Ki | = | 3420.0 | nM | 5.47 |
| CHEMBL3092747 | — | Ki | = | 3530.0 | nM | 5.45 |
| CHEMBL1163022 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL256208 | — | Ki | = | 3690.0 | nM | 5.43 |
| CHEMBL593618 | — | Ki | = | 3920.0 | nM | 5.41 |
| CHEMBL593165 | — | Ki | = | 4190.0 | nM | 5.38 |
| CHEMBL14060 | PHENOL | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL3092746 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3092752 | — | Ki | > | 100000.0 | nM | - |