Assay Detail
Binding
CHEMBL3095677
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Binding affinity to 5-HT2A receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.06 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294951 | PIZOTYLINE | 2.0 | 1 | 8.12 |
| CHEMBL3092753 | — | — | 1 | 6.00 |
| CHEMBL3092759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294951 | PIZOTYLINE | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL3092753 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3092759 | — | Ki | > | 1000.0 | nM | - |