Assay Detail
Binding
CHEMBL3095701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Sgk1 (CHEMBL2343) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-[4-(1H-Pyrazolo[3,4-B]pyrazin-6yl)-phenyl]-sulonamides and Their Use As Pharmaceuticals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.81 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092461 | — | — | 1 | 6.20 |
| CHEMBL3092468 | — | — | 1 | 6.16 |
| CHEMBL3092460 | — | — | 1 | 5.85 |
| CHEMBL3092467 | — | — | 1 | 5.82 |
| CHEMBL3092464 | — | — | 1 | 5.82 |
| CHEMBL3092462 | — | — | 1 | 5.68 |
| CHEMBL3092466 | — | — | 1 | 5.62 |
| CHEMBL3092463 | — | — | 1 | 5.58 |
| CHEMBL3092465 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092461 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3092468 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3092460 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3092467 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3092464 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3092462 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3092466 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3092463 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3092465 | — | IC50 | = | 2900.0 | nM | 5.54 |