Assay Detail
Binding
CHEMBL3095702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human SGK-1 expressed in baculovirus expression system using (5(6)-carboxyfluorescein)-RPRAATF-NH2 as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Sgk1 (CHEMBL2343) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-[4-(1H-Pyrazolo[3,4-B]pyrazin-6yl)-phenyl]-sulonamides and Their Use As Pharmaceuticals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.62 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092468 | — | — | 1 | 9.00 |
| CHEMBL3092467 | — | — | 1 | 8.70 |
| CHEMBL3092466 | — | — | 1 | 8.70 |
| CHEMBL3092463 | — | — | 1 | 8.70 |
| CHEMBL3092462 | — | — | 1 | 8.70 |
| CHEMBL3092465 | — | — | 1 | 8.52 |
| CHEMBL3092460 | — | — | 1 | 8.52 |
| CHEMBL3092464 | — | — | 1 | 8.40 |
| CHEMBL3092461 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092468 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3092467 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092466 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092463 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092462 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092465 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3092460 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3092464 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3092461 | — | IC50 | = | 5.0 | nM | 8.30 |