Assay Detail
Binding
CHEMBL3095874
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Inhibition of human MAO-B
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 5.73 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.21 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 8.12 |
| CHEMBL26138 | — | — | 1 | 7.75 |
| CHEMBL3093236 | — | — | 1 | 7.20 |
| CHEMBL3093239 | — | — | 1 | 7.06 |
| CHEMBL3093237 | — | — | 1 | 6.71 |
| CHEMBL241617 | — | — | 1 | 6.66 |
| CHEMBL241618 | — | — | 1 | 6.46 |
| CHEMBL239230 | — | — | 1 | 6.21 |
| CHEMBL3093238 | — | — | 1 | 5.87 |
| CHEMBL3093311 | — | — | 1 | 5.75 |
| CHEMBL3093241 | — | — | 1 | 5.66 |
| CHEMBL3093221 | — | — | 1 | 5.53 |
| CHEMBL3093225 | — | — | 1 | 5.49 |
| CHEMBL3093216 | — | — | 1 | 5.46 |
| CHEMBL3093223 | — | — | 1 | 5.44 |
| CHEMBL3093230 | — | — | 1 | 5.43 |
| CHEMBL3093310 | — | — | 1 | 5.42 |
| CHEMBL3093227 | — | — | 1 | 5.32 |
| CHEMBL3093232 | — | — | 1 | 5.30 |
| CHEMBL3093228 | — | — | 1 | 5.23 |
| CHEMBL3093224 | — | — | 1 | 5.19 |
| CHEMBL3093326 | — | — | 1 | 5.00 |
| CHEMBL3093325 | — | — | 1 | 5.00 |
| CHEMBL3093312 | — | — | 1 | 5.00 |
| CHEMBL3093313 | — | — | 1 | 5.00 |
| CHEMBL3093315 | — | — | 1 | 5.00 |
| CHEMBL3093234 | — | — | 1 | 5.00 |
| CHEMBL3093333 | — | — | 1 | 5.00 |
| CHEMBL3093233 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 6.13 | nM | 8.21 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 7.67 | nM | 8.12 |
| CHEMBL26138 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL3093236 | — | IC50 | = | 62.9 | nM | 7.20 |
| CHEMBL3093239 | — | IC50 | = | 86.9 | nM | 7.06 |
| CHEMBL3093237 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL241617 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL241618 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL239230 | — | IC50 | = | 624.0 | nM | 6.21 |
| CHEMBL3093238 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL3093311 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3093241 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3093221 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL3093225 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL3093216 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL3093223 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3093230 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL3093310 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL3093227 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL3093232 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL3093228 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL3093224 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL3093219 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093218 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093214 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093313 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093240 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093331 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093233 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093234 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093315 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093312 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093325 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093326 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093333 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3093323 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093322 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093321 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3091482 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093320 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093319 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093318 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093317 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093316 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL282038 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093314 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093329 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093226 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3093332 | — | IC50 | > | 10000.0 | nM | - |