Assay Detail
Binding
CHEMBL3095999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.03 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371405 | MARIZOMIB | 3.0 | 1 | 7.66 |
| CHEMBL192046 | — | — | 1 | 7.64 |
| CHEMBL3092609 | — | — | 1 | 7.55 |
| CHEMBL3092608 | — | — | 1 | 7.30 |
| CHEMBL3092611 | — | — | 1 | 6.48 |
| CHEMBL3092612 | — | — | 1 | 6.30 |
| CHEMBL3092610 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371405 | MARIZOMIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL192046 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3092609 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3092608 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3092611 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3092612 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3092610 | — | IC50 | = | 500.0 | nM | 6.30 |