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Assay Detail

CHEMBL3096019

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and cytotoxicity of novel 3'-N-alkoxycarbonyl docetaxel analogs.
Chang J, Hao XD, Hao YP, Lu HF, Yu JM, Sun X.
Bioorg Med Chem Lett (2013) 23 : 6834 -6837
PubMed 24269481 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.29 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3092641 1 8.00
CHEMBL3092642 1 7.92
CHEMBL3092640 1 7.89
CHEMBL3092638 1 7.75
CHEMBL3092637 1 7.52
CHEMBL3092635 1 7.46
CHEMBL3092639 1 7.40
CHEMBL3092634 1 7.33
CHEMBL3092636 1 7.22
CHEMBL446326 1 6.85
CHEMBL3545252 DOCETAXEL 4.0 1 6.07
CHEMBL428647 PACLITAXEL 4.0 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3092641 IC50 = 10.0 nM 8.00
CHEMBL3092642 IC50 = 12.0 nM 7.92
CHEMBL3092640 IC50 = 13.0 nM 7.89
CHEMBL3092638 IC50 = 18.0 nM 7.75
CHEMBL3092637 IC50 = 30.0 nM 7.52
CHEMBL3092635 IC50 = 35.0 nM 7.46
CHEMBL3092639 IC50 = 40.0 nM 7.40
CHEMBL3092634 IC50 = 47.0 nM 7.33
CHEMBL3092636 IC50 = 60.0 nM 7.22
CHEMBL446326 IC50 = 140.0 nM 6.85
CHEMBL3545252 DOCETAXEL IC50 = 850.0 nM 6.07
CHEMBL428647 PACLITAXEL IC50 = 930.0 nM 6.03