Assay Detail
Binding
CHEMBL3096027
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Inhibition of HIV-1 gp41-mediated 6-helix bundle formation after 30 mins by sandwich ELISA
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Small molecule fusion inhibitors: design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.01 | 6.05 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092871 | — | — | 1 | 6.05 |
| CHEMBL3092878 | — | — | 1 | 5.75 |
| CHEMBL3092872 | — | — | 1 | 5.75 |
| CHEMBL3092877 | — | — | 1 | 5.68 |
| CHEMBL3092874 | — | — | 1 | 5.58 |
| CHEMBL3092876 | — | — | 1 | 5.11 |
| CHEMBL3092875 | — | — | 1 | 5.04 |
| CHEMBL3092870 | — | — | 1 | 4.99 |
| CHEMBL3092867 | — | — | 1 | 4.92 |
| CHEMBL3092868 | — | — | 1 | 4.90 |
| CHEMBL3092869 | — | — | 1 | 4.73 |
| CHEMBL3092879 | — | — | 1 | 4.68 |
| CHEMBL3092880 | — | — | 1 | 4.65 |
| CHEMBL3092882 | — | — | 1 | 4.46 |
| CHEMBL214344 | — | — | 1 | 4.43 |
| CHEMBL3092865 | — | — | 1 | 4.34 |
| CHEMBL3092873 | — | — | 1 | 4.17 |
| CHEMBL3092881 | — | — | 1 | - |
| CHEMBL3092866 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092871 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3092878 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3092872 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3092877 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3092874 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3092876 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3092875 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3092870 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3092867 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL3092868 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3092869 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL3092879 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL3092880 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL3092882 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL214344 | — | IC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL3092865 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL3092873 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3092881 | — | IC50 | - | — | - | |
| CHEMBL3092866 | — | Inhibition | - | % | - |