Assay Detail
Binding
CHEMBL3096100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human adenosine A2B receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.32 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093327 | — | — | 1 | 6.73 |
| CHEMBL282038 | — | — | 1 | 5.38 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.04 |
| CHEMBL3093328 | — | — | 1 | 5.00 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.47 |
| CHEMBL413079 | — | — | 1 | - |
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093327 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL282038 | — | Ki | = | 4130.0 | nM | 5.38 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 9070.0 | nM | 5.04 |
| CHEMBL3093328 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL113 | CAFFEINE | Ki | = | 33800.0 | nM | 4.47 |
| CHEMBL413079 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL431770 | ISTRADEFYLLINE | Ki | > | 10000.0 | nM | - |