Assay Detail
Binding
CHEMBL3096291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MDR1 in human doxorubicin-resistant A2780adr cells assessed as Calcein AM accumulation treated 30 mins before Calcein AM addition measured up to 90 mins by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2780 ADR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.19 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.04 |
| CHEMBL3092483 | — | — | 1 | 5.46 |
| CHEMBL2158554 | — | — | 1 | 5.23 |
| CHEMBL3092485 | — | — | 1 | 5.02 |
| CHEMBL3092482 | — | — | 1 | 4.93 |
| CHEMBL2158551 | — | — | 1 | 4.91 |
| CHEMBL3092490 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3092483 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL2158554 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL3092485 | — | IC50 | = | 9560.0 | nM | 5.02 |
| CHEMBL3092482 | — | IC50 | = | 11760.0 | nM | 4.93 |
| CHEMBL2158551 | — | IC50 | = | 12380.0 | nM | 4.91 |
| CHEMBL3092490 | — | IC50 | = | 18210.0 | nM | 4.74 |