Assay Detail
Functional
CHEMBL3096511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovalbumin-induced antigen presentation in mouse A20 cells treated 1 hr before ovalbumin addition incubated for 16 hrs followed by co-cultured with DO10.10 T-cell hybridoma cells for 24 hrs assessed as IL-2 production by luminex single-bead analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | A20 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.21 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093822 | — | — | 1 | 9.00 |
| CHEMBL3093935 | — | — | 1 | 8.70 |
| CHEMBL3093942 | — | — | 1 | 8.70 |
| CHEMBL3093826 | — | — | 1 | 8.70 |
| CHEMBL3093941 | — | — | 1 | 8.52 |
| CHEMBL3093825 | — | — | 1 | 8.30 |
| CHEMBL3093947 | — | — | 1 | 7.92 |
| CHEMBL3093934 | — | — | 1 | 7.82 |
| CHEMBL3093823 | — | — | 1 | 7.80 |
| CHEMBL3093827 | — | — | 1 | 7.77 |
| CHEMBL3093936 | — | — | 1 | 7.72 |
| CHEMBL3093940 | — | — | 1 | 7.64 |
| CHEMBL3093928 | — | — | 1 | 7.54 |
| CHEMBL3093946 | — | — | 1 | 7.37 |
| CHEMBL3093929 | — | — | 1 | 7.36 |
| CHEMBL3093932 | — | — | 1 | 7.24 |
| CHEMBL3093931 | — | — | 1 | 7.04 |
| CHEMBL3093945 | — | — | 1 | 6.93 |
| CHEMBL3093944 | — | — | 1 | 6.68 |
| CHEMBL3093933 | — | — | 1 | 6.66 |
| CHEMBL3093948 | — | — | 1 | 6.63 |
| CHEMBL3093824 | — | — | 1 | 6.61 |
| CHEMBL3093829 | — | — | 1 | 6.43 |
| CHEMBL3093927 | — | — | 1 | 6.41 |
| CHEMBL3093930 | — | — | 1 | 6.24 |
| CHEMBL3093926 | — | — | 1 | 6.09 |
| CHEMBL3093938 | — | — | 1 | 6.03 |
| CHEMBL3093828 | — | — | 1 | 5.87 |
| CHEMBL3093943 | — | — | 1 | 5.37 |
| CHEMBL3093939 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093822 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3093935 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3093942 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3093826 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3093941 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3093825 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3093947 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3093934 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3093823 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3093827 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3093936 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3093940 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3093928 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3093946 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3093929 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3093932 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3093931 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3093945 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL3093944 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3093933 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL3093948 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL3093824 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL3093829 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL3093927 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL3093930 | — | IC50 | = | 572.0 | nM | 6.24 |
| CHEMBL3093926 | — | IC50 | = | 816.0 | nM | 6.09 |
| CHEMBL3093938 | — | IC50 | = | 925.0 | nM | 6.03 |
| CHEMBL3093828 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3093943 | — | IC50 | = | 4239.0 | nM | 5.37 |
| CHEMBL3093939 | — | IC50 | = | 4506.0 | nM | 5.35 |