Assay Detail
Binding
CHEMBL3096532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PDE10A (unknown origin) expressed in baculovirus infected insect SF-21 cells using [3H]-cAMP as substrate after 30 mins by liquid scintillation counting analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SF-21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL4409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PDE2 inhibition: potential for the treatment of cognitive disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.52 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2070639 | — | — | 1 | 7.68 |
| CHEMBL3092557 | — | — | 1 | 7.35 |
| CHEMBL3092558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2070639 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3092557 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3092558 | — | IC50 | > | 1000.0 | nM | - |