Assay Detail
Functional
CHEMBL3096580
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Agonist activity at recombinant human GPR39 expressed in CHO-K1 cells assessed as increase of Zn2+-induced cAMP production preincubated for 30 mins measured after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.72 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092411 | — | — | 1 | 6.51 |
| CHEMBL3092410 | — | — | 1 | 6.08 |
| CHEMBL3092412 | — | — | 1 | 5.35 |
| CHEMBL3092413 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092411 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3092410 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3092412 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3092413 | — | EC50 | = | 12000.0 | nM | 4.92 |