Assay Detail
Binding
CHEMBL3096582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human GPR39 expressed in CHO-K1 cells assessed as increase of Zn2+-induced intracellular Ca+2 mobilization after 1 hr by Fluo-4 No staining-based FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.50 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092413 | — | — | 1 | 7.25 |
| CHEMBL3092410 | — | — | 1 | 6.72 |
| CHEMBL3092411 | — | — | 1 | 6.50 |
| CHEMBL3092412 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092413 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3092410 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3092411 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3092412 | — | EC50 | = | 3100.0 | nM | 5.51 |