Assay Detail
Binding
CHEMBL3096737
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Inhibition of Sprague-Dawley rat MAO-A using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to substrate addition measured for 5 mins by spectrophotometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.36 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3094011 | — | — | 1 | 6.55 |
| CHEMBL575093 | — | — | 1 | 6.33 |
| CHEMBL575931 | — | — | 1 | 6.30 |
| CHEMBL572534 | — | — | 1 | 5.70 |
| CHEMBL3094007 | — | — | 1 | 5.39 |
| CHEMBL3094030 | — | — | 1 | 5.38 |
| CHEMBL575934 | — | — | 1 | 5.28 |
| CHEMBL239507 | — | — | 1 | 5.23 |
| CHEMBL3094017 | — | — | 1 | 5.05 |
| CHEMBL3094024 | — | — | 1 | 5.05 |
| CHEMBL3094008 | — | — | 1 | 5.03 |
| CHEMBL3094037 | — | — | 1 | 4.99 |
| CHEMBL3093992 | — | — | 1 | 4.93 |
| CHEMBL3094016 | — | — | 1 | 4.62 |
| CHEMBL575738 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3094011 | — | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL575093 | — | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL575931 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL572534 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL3094007 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL3094030 | — | IC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL575934 | — | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL239507 | — | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL3094017 | — | IC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL3094024 | — | IC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL3094008 | — | IC50 | = | 9332.54 | nM | 5.03 |
| CHEMBL3094037 | — | IC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL3093992 | — | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL3094016 | — | IC50 | = | 23988.33 | nM | 4.62 |
| CHEMBL575738 | — | IC50 | = | 25703.96 | nM | 4.59 |