Assay Detail
Functional
CHEMBL3096864
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Cytotoxicity against human MCF-7 cells assessed as growth inhibition after 72 hrs by WST-1 assay
50
Total Activities
50
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 8.53 | 10.68 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3094252 | — | — | 1 | 10.68 |
| CHEMBL3094260 | — | — | 1 | 10.44 |
| CHEMBL3094264 | — | — | 1 | 10.39 |
| CHEMBL3094234 | — | — | 1 | 10.30 |
| CHEMBL3094263 | — | — | 1 | 10.00 |
| CHEMBL3094257 | — | — | 1 | 10.00 |
| CHEMBL3094258 | — | — | 1 | 9.96 |
| CHEMBL3094259 | — | — | 1 | 9.54 |
| CHEMBL3094248 | — | — | 1 | 9.51 |
| CHEMBL3094255 | — | — | 1 | 9.48 |
| CHEMBL3094235 | — | — | 1 | 9.43 |
| CHEMBL3094250 | — | — | 1 | 9.38 |
| CHEMBL3094218 | — | — | 1 | 9.20 |
| CHEMBL3094238 | — | — | 1 | 9.03 |
| CHEMBL2417795 | — | — | 1 | 9.00 |
| CHEMBL3094219 | — | — | 1 | 9.00 |
| CHEMBL3094237 | — | — | 1 | 8.85 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 8.80 |
| CHEMBL3094222 | — | — | 1 | 8.77 |
| CHEMBL3094256 | — | — | 1 | 8.54 |
| CHEMBL3094254 | — | — | 1 | 8.47 |
| CHEMBL3094242 | — | — | 1 | 8.44 |
| CHEMBL3094221 | — | — | 1 | 8.28 |
| CHEMBL3094236 | — | — | 1 | 8.26 |
| CHEMBL3094243 | — | — | 1 | 8.24 |
| CHEMBL3094241 | — | — | 1 | 8.19 |
| CHEMBL3094247 | — | — | 1 | 8.15 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 8.13 |
| CHEMBL3094240 | — | — | 1 | 8.13 |
| CHEMBL3094229 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3094252 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL3094260 | — | IC50 | = | 0.036 | nM | 10.44 |
| CHEMBL3094264 | — | IC50 | = | 0.041 | nM | 10.39 |
| CHEMBL3094234 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL3094263 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3094257 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3094258 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL3094259 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL3094248 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL3094255 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL3094235 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL3094250 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL3094218 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL3094238 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL3094219 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2417795 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3094237 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL17289 | CHS-828 | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3094222 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3094256 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3094254 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3094242 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3094221 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3094236 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3094243 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3094241 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3094247 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3094240 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3094229 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3094245 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3094228 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3094227 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL3094244 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3094225 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3094231 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL3094224 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL3094226 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3094239 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3094232 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL3094230 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL3094220 | — | IC50 | = | 38.3 | nM | 7.42 |
| CHEMBL3094233 | — | IC50 | = | 46.3 | nM | 7.33 |
| CHEMBL3094246 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3094249 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3094253 | — | IC50 | = | 1016.0 | nM | 5.99 |
| CHEMBL3094251 | — | Inhibition | - | % | - | |
| CHEMBL3094261 | — | Inhibition | - | % | - | |
| CHEMBL3094262 | — | IC50 | = | 0.007 | nM | - |
| CHEMBL3094223 | — | Inhibition | - | % | - |