Assay Detail
Binding
CHEMBL3097095
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Displacement of [3H]nisoxetine from norepinephrine transporter in rat cerebral cortex after 120 mins by liquid scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.03 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093268 | — | — | 1 | 6.10 |
| CHEMBL113621 | — | — | 1 | 5.96 |
| CHEMBL112125 | — | — | 1 | - |
| CHEMBL325262 | — | — | 1 | - |
| CHEMBL3093270 | — | — | 1 | - |
| CHEMBL3093269 | — | — | 1 | - |
| CHEMBL145867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093268 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL113621 | — | Ki | = | 1107.0 | nM | 5.96 |
| CHEMBL112125 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL325262 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093270 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3093269 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL145867 | — | Ki | > | 10000.0 | nM | - |