Assay Detail
Binding
CHEMBL3097102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]di-o-tolylguanidine from sigma2 receptor in rat brain after 120 mins by liquid scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.73 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145867 | — | — | 1 | 8.31 |
| CHEMBL3093270 | — | — | 1 | 8.11 |
| CHEMBL112125 | — | — | 1 | 7.96 |
| CHEMBL325262 | — | — | 1 | 7.90 |
| CHEMBL3093269 | — | — | 1 | 7.48 |
| CHEMBL3093268 | — | — | 1 | 7.25 |
| CHEMBL113621 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145867 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL3093270 | — | Ki | = | 7.79 | nM | 8.11 |
| CHEMBL112125 | — | Ki | = | 10.89 | nM | 7.96 |
| CHEMBL325262 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL3093269 | — | Ki | = | 33.3 | nM | 7.48 |
| CHEMBL3093268 | — | Ki | = | 56.32 | nM | 7.25 |
| CHEMBL113621 | — | Ki | = | 82.31 | nM | 7.08 |