Assay Detail
Binding
CHEMBL3097144
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Binding affinity to human histamine H1 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.70 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783890 | — | — | 1 | 5.80 |
| CHEMBL3092650 | GSK239512 | 2.0 | 1 | 5.60 |
| CHEMBL517140 | GSK189254 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783890 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL3092650 | GSK239512 | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL517140 | GSK189254 | Ki | > | 2511.89 | nM | - |