Assay Detail

CHEMBL3097158

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Binding

Antagonist activity at human 5-HT3B receptor E170A mutant assessed as inhibition of 5-HT-induced response after 45 mins by FLIPR assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor.

Del Cadia M, De Rienzo F, Weston DA, Thompson AJ, Menziani MC, Lummis SC.
Bioorg Med Chem (2013) 21 : 7523 -7528
PubMed 24128813 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.44	9.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1189679	PALONOSETRON	4.0	1	9.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1189679	PALONOSETRON	IC50	=	0.36	nM	9.44