Assay Detail
Binding
CHEMBL3097223
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Antagonist activity at CXCR4 in human PBMC assessed as inhibition of HIV-1 3B infection
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tetrahydroisoquinoline-based CXCR4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.50 | 7.52 |
| IC90 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | 7.52 |
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | — | 1 | 7.52 |
| CHEMBL3091687 | — | — | 2 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518924 | MAVORIXAFOR | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3091687 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3091687 | — | IC90 | = | 240.0 | nM | - |