Assay Detail
Binding
CHEMBL3097228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CXCR4 in human MAGI-CCR5 cells assessed as inhibition of HIV-1 3B entry after 2 to 6 days by beta-galactosidase reporter gene assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MAGI-CCR5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tetrahydroisoquinoline-based CXCR4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.06 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3091687 | — | — | 1 | 8.30 |
| CHEMBL3091693 | — | — | 1 | 7.70 |
| CHEMBL3091694 | — | — | 1 | 7.70 |
| CHEMBL3091681 | — | — | 1 | 7.52 |
| CHEMBL3091682 | — | — | 1 | 7.40 |
| CHEMBL3091691 | — | — | 1 | 7.40 |
| CHEMBL3091690 | — | — | 1 | 7.22 |
| CHEMBL3091688 | — | — | 1 | 7.22 |
| CHEMBL3091689 | — | — | 1 | 7.16 |
| CHEMBL3091692 | — | — | 1 | 7.10 |
| CHEMBL3091683 | — | — | 1 | 6.92 |
| CHEMBL3091685 | — | — | 1 | 6.68 |
| CHEMBL3091678 | — | — | 1 | 6.60 |
| CHEMBL3091684 | — | — | 1 | 6.54 |
| CHEMBL3091686 | — | — | 1 | 6.38 |
| CHEMBL3091676 | — | — | 1 | 6.35 |
| CHEMBL3091677 | — | — | 1 | 5.87 |
| CHEMBL3091680 | — | — | 1 | - |
| CHEMBL3091679 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3091687 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3091693 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3091694 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3091681 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3091682 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3091691 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3091690 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3091688 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3091689 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3091692 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3091683 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3091685 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3091678 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3091684 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3091686 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3091676 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3091677 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL3091680 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3091679 | — | IC50 | > | 30000.0 | nM | - |