Assay Detail
Functional
CHEMBL3097474
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Antiinflammatory activity in human PBMC assessed as inhibition of IL-17 production after 48 hrs by Sandwich ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.13 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3094369 | — | — | 1 | 6.88 |
| CHEMBL3094367 | — | — | 1 | 6.00 |
| CHEMBL62136 | T091317 | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3094369 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL3094367 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL62136 | T091317 | EC50 | = | 3000.0 | nM | 5.52 |