Assay Detail
Binding
CHEMBL3097789
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Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 8.20 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3091556 | — | — | 1 | 9.28 |
| CHEMBL3091466 | — | — | 1 | 9.27 |
| CHEMBL3091552 | — | — | 1 | 9.10 |
| CHEMBL3091565 | — | — | 1 | 9.00 |
| CHEMBL3091572 | — | — | 1 | 8.96 |
| CHEMBL3091549 | — | — | 1 | 8.92 |
| CHEMBL3091566 | — | — | 1 | 8.92 |
| CHEMBL3091729 | — | — | 1 | 8.92 |
| CHEMBL3091574 | — | — | 1 | 8.89 |
| CHEMBL3091577 | — | — | 1 | 8.89 |
| CHEMBL3091736 | — | — | 1 | 8.89 |
| CHEMBL3091550 | — | — | 1 | 8.85 |
| CHEMBL3091551 | — | — | 1 | 8.80 |
| CHEMBL3091548 | — | — | 1 | 8.80 |
| CHEMBL3091554 | — | — | 1 | 8.80 |
| CHEMBL3091571 | — | — | 1 | 8.66 |
| CHEMBL3091734 | — | — | 1 | 8.66 |
| CHEMBL3091568 | — | — | 1 | 8.64 |
| CHEMBL3091563 | — | — | 1 | 8.57 |
| CHEMBL3091732 | — | — | 1 | 8.55 |
| CHEMBL3091553 | — | — | 1 | 8.28 |
| CHEMBL2105737 | SONIDEGIB | 4.0 | 1 | 8.26 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 8.14 |
| CHEMBL3091558 | — | — | 1 | 7.97 |
| CHEMBL3091559 | — | — | 1 | 7.80 |
| CHEMBL3091733 | — | — | 1 | 7.70 |
| CHEMBL3091555 | — | — | 1 | 7.63 |
| CHEMBL3091560 | — | — | 1 | 7.48 |
| CHEMBL3091562 | — | — | 1 | 7.46 |
| CHEMBL3091564 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3091556 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL3091466 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL3091552 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3091565 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3091572 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3091549 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3091566 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3091729 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3091574 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3091577 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3091736 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3091550 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3091551 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3091548 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3091554 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3091571 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3091734 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3091568 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3091563 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3091732 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3091553 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2105737 | SONIDEGIB | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3091558 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL3091559 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL3091733 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL3091555 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL3091560 | — | IC50 | = | 32.8 | nM | 7.48 |
| CHEMBL3091562 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL3091564 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL3091570 | — | IC50 | = | 73.1 | nM | 7.14 |
| CHEMBL3091573 | — | IC50 | = | 100.6 | nM | 7.00 |
| CHEMBL3091567 | — | IC50 | = | 118.3 | nM | 6.93 |
| CHEMBL3091575 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3091561 | — | IC50 | = | 151.5 | nM | 6.82 |
| CHEMBL3091731 | — | IC50 | = | 158.5 | nM | 6.80 |
| CHEMBL3091569 | — | IC50 | = | 353.6 | nM | 6.45 |
| CHEMBL3091557 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3091735 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3091730 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3091576 | — | IC50 | > | 500.0 | nM | - |