Assay Detail
Binding
CHEMBL3097934
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Inhibition of human carbonic anhydrase 2 by CO2 hydration assay
23
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.46 | 6.30 |
| Ki | 2 | 5.79 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | 4.0 | 2 | 6.52 |
| CHEMBL3092995 | JNJ-26489112 | 2.0 | 2 | 5.06 |
| CHEMBL3093012 | — | — | 1 | 4.77 |
| CHEMBL3093001 | — | — | 1 | 4.60 |
| CHEMBL3093010 | — | — | 1 | 4.54 |
| CHEMBL3093009 | — | — | 1 | 4.52 |
| CHEMBL3093007 | — | — | 1 | 4.44 |
| CHEMBL3093003 | — | — | 1 | 4.44 |
| CHEMBL3093004 | — | — | 1 | 4.25 |
| CHEMBL3093005 | — | — | 1 | 4.16 |
| CHEMBL177623 | — | — | 1 | 4.15 |
| CHEMBL3093006 | — | — | 1 | 4.12 |
| CHEMBL3092998 | — | — | 1 | 4.11 |
| CHEMBL3092999 | — | — | 1 | 4.07 |
| CHEMBL3092997 | — | — | 1 | 4.01 |
| CHEMBL3093000 | — | — | 1 | - |
| CHEMBL3092996 | — | — | 1 | - |
| CHEMBL175644 | — | — | 1 | - |
| CHEMBL3093002 | — | — | 1 | - |
| CHEMBL3093008 | — | — | 1 | - |
| CHEMBL3093011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL220492 | TOPIRAMATE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3092995 | JNJ-26489112 | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL3093012 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3093001 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3093010 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3093009 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3092995 | JNJ-26489112 | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3093007 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3093003 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3093004 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL3093005 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL177623 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL3093006 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL3092998 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL3092999 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL3092997 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL3093000 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3092996 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL175644 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL3093002 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL3093008 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL3093011 | — | IC50 | - | — | - |