Assay Detail
Binding
CHEMBL3100233
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Inhibition of human recombinant COX2 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.92 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.70 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.40 |
| CHEMBL3100129 | — | — | 1 | 6.16 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.02 |
| CHEMBL3100124 | — | — | 1 | 5.21 |
| CHEMBL3100127 | — | — | 1 | 5.14 |
| CHEMBL3100125 | — | — | 1 | 5.10 |
| CHEMBL117 | CHRYSIN | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL118 | CELECOXIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3100129 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3100124 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3100127 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3100125 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL117 | CHRYSIN | IC50 | = | 25500.0 | nM | 4.59 |