Assay Detail
Binding
CHEMBL3100235
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Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as dopachrome formation after 5 mins by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.58 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443605 | HEXYLRESORCINOL | -1.0 | 1 | 6.25 |
| CHEMBL3100130 | — | — | 1 | 5.82 |
| CHEMBL3100134 | — | — | 1 | 5.76 |
| CHEMBL3100132 | — | — | 1 | 5.64 |
| CHEMBL3100135 | — | — | 1 | 5.42 |
| CHEMBL3100133 | — | — | 1 | 5.34 |
| CHEMBL3100131 | — | — | 1 | 5.33 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443605 | HEXYLRESORCINOL | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3100130 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL3100134 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL3100132 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3100135 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL3100133 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL3100131 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 9150.0 | nM | 5.04 |