Assay Detail
Binding
CHEMBL3100250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition measured for 20 mins by turbidometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.89 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099864 | — | — | 1 | 6.32 |
| CHEMBL3099862 | — | — | 1 | 6.28 |
| CHEMBL3099863 | — | — | 1 | 6.17 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL3099861 | — | — | 1 | 5.89 |
| CHEMBL227027 | — | — | 1 | 5.68 |
| CHEMBL3099860 | — | — | 1 | 5.50 |
| CHEMBL371795 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099864 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3099862 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3099863 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3099861 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL227027 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3099860 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL371795 | — | IC50 | = | 4200.0 | nM | 5.38 |