Assay Detail
Functional
CHEMBL3100255
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Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by coulter counting analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.86 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL3099862 | — | — | 1 | 8.10 |
| CHEMBL3099860 | — | — | 1 | 7.89 |
| CHEMBL3099864 | — | — | 1 | 7.89 |
| CHEMBL3099863 | — | — | 1 | 7.80 |
| CHEMBL3099865 | — | — | 1 | 7.18 |
| CHEMBL3099850 | — | — | 1 | 7.16 |
| CHEMBL3099861 | — | — | 1 | 7.00 |
| CHEMBL3099853 | — | — | 1 | 7.00 |
| CHEMBL3099855 | — | — | 1 | 6.70 |
| CHEMBL3099854 | — | — | 1 | 6.66 |
| CHEMBL3099849 | — | — | 1 | 6.44 |
| CHEMBL3099856 | — | — | 1 | 6.16 |
| CHEMBL3099857 | — | — | 1 | 6.12 |
| CHEMBL3099852 | — | — | 1 | 5.82 |
| CHEMBL3099851 | — | — | 1 | 5.80 |
| CHEMBL3099858 | — | — | 1 | 5.80 |
| CHEMBL3099859 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3099862 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3099860 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3099864 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3099863 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3099865 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3099850 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3099861 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3099853 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3099855 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3099854 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3099849 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3099856 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3099857 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3099852 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3099851 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3099858 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3099859 | — | IC50 | = | 6300.0 | nM | 5.20 |