Assay Detail
Functional
CHEMBL3100268
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP production after 20 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR study of a novel series of dopamine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 8.50 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099226 | — | — | 1 | 9.85 |
| CHEMBL3098131 | — | — | 1 | 9.77 |
| CHEMBL3099235 | — | — | 1 | 9.30 |
| CHEMBL3099222 | — | — | 1 | 9.22 |
| CHEMBL1303 | ROTIGOTINE | 4.0 | 1 | 9.15 |
| CHEMBL3099225 | — | — | 1 | 9.10 |
| CHEMBL3099231 | — | — | 1 | 9.00 |
| CHEMBL3099227 | — | — | 1 | 8.96 |
| CHEMBL3099230 | — | — | 1 | 8.82 |
| CHEMBL3099234 | — | — | 1 | 8.77 |
| CHEMBL3099236 | — | — | 1 | 8.68 |
| CHEMBL3099239 | — | — | 1 | 8.46 |
| CHEMBL3099224 | — | — | 1 | 8.40 |
| CHEMBL3099232 | — | — | 1 | 7.89 |
| CHEMBL3099228 | — | — | 1 | 7.75 |
| CHEMBL3099223 | — | — | 1 | 7.60 |
| CHEMBL3099233 | — | — | 1 | 7.48 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.44 |
| CHEMBL3099229 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099226 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3098131 | — | EC50 | = | 0.17 | nM | 9.77 |
| CHEMBL3099235 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3099222 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1303 | ROTIGOTINE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3099225 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3099231 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3099227 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3099230 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3099234 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3099236 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3099239 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3099224 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3099232 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3099228 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3099223 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3099233 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL59 | DOPAMINE | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3099229 | — | EC50 | = | 1400.0 | nM | 5.85 |