Assay Detail
Binding
CHEMBL3100299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate Lineweaver-Burk plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.21 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099618 | — | — | 1 | 6.47 |
| CHEMBL3099624 | — | — | 1 | 6.17 |
| CHEMBL3099621 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099618 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL3099624 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL3099621 | — | Ki | = | 1020.0 | nM | 5.99 |