Assay Detail
Functional
CHEMBL3100671
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Antimalarial activity against Plasmodium falciparum K1 infected in human RBC after 72 hrs by hypoxanthine incorporation assay in presence of serum albumin
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.82 | 8.05 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL530733 | — | — | 1 | 8.05 |
| CHEMBL3099040 | — | — | 1 | 7.80 |
| CHEMBL601604 | — | — | 1 | 7.57 |
| CHEMBL3099041 | — | — | 1 | 6.97 |
| CHEMBL3099044 | — | — | 1 | 6.78 |
| CHEMBL589703 | — | — | 1 | 6.56 |
| CHEMBL3099392 | — | — | 1 | 6.46 |
| CHEMBL3099042 | — | — | 1 | 6.35 |
| CHEMBL3099043 | — | — | 1 | 6.15 |
| CHEMBL3099045 | — | — | 1 | 5.48 |
| CHEMBL3099394 | — | — | 1 | - |
| CHEMBL3099393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL530733 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3099040 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL601604 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3099041 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL3099044 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL589703 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL3099392 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL3099042 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL3099043 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL3099045 | — | IC50 | = | 3313.0 | nM | 5.48 |
| CHEMBL3099394 | — | Activity | - | — | - | |
| CHEMBL3099393 | — | Activity | - | — | - |