Assay Detail
Binding
CHEMBL3100993
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Inhibition of Nampt (unknown origin) using nicotinamide as substrate preincubated for 15 mins measured after 30 mins by mass spectrometry analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.50 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098518 | — | — | 1 | 9.22 |
| CHEMBL3098517 | — | — | 1 | 8.77 |
| CHEMBL3098610 | — | — | 1 | 8.72 |
| CHEMBL3098516 | — | — | 1 | 8.70 |
| CHEMBL3098512 | — | — | 1 | 8.66 |
| CHEMBL3098608 | — | — | 1 | 8.62 |
| CHEMBL3098511 | — | — | 1 | 8.62 |
| CHEMBL3098510 | — | — | 1 | 8.60 |
| CHEMBL3098611 | — | — | 1 | 8.44 |
| CHEMBL3098609 | — | — | 1 | 8.36 |
| CHEMBL3098513 | — | — | 1 | 8.36 |
| CHEMBL3098515 | — | — | 1 | 8.27 |
| CHEMBL3098514 | — | — | 1 | 8.12 |
| CHEMBL2419503 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098518 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3098517 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3098610 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3098516 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3098512 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3098608 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3098511 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3098510 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3098611 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3098609 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3098513 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3098515 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3098514 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL2419503 | — | IC50 | = | 29.0 | nM | 7.54 |